【關鍵詞】 ,宮內感染
Relationship between serum hepatitis B virus DNA load and intrauterine infection in pregnant women
【Abstract】 AIM: To study the relationship between serum hepatitis B virus (HBV) DNA load in pregnant women and intrauterine infection as well as other relative factors. METHODS: Two hundred and twentyeight cases of HBsAg positive pregnant women were screened out by ELISA. HBVDNA content was detected with fluorescence quantitative polymerase chain reaction （PCR）in HBsAg positive pregnant women and their fetal cord blood. According to the results of HBVDNA, the newborns were divided into infected group and noninfected group（control group）. Relative factors were investigated in infected group and control group with intrauterine infection. RESULTS: Cord blood positivity rate of HBVDNA was 21％（14/68）in HBsAg, HBeAg and antiHBc positive pregnant women, 1.7％（2/117）in HBsAg, antiHBe and antiHBc positive pregnant women, 20％（3/15）in HBsAg and HBeAg positive pregnant women, and 11％（2/19）in HBsAg and antiHBc positive pregnant women. HBVDNA was not detected in only HBsAg positive pregnant women. The total infection rate in fetus was 9.2％. Intrauterine infection rate increased significantly when HBVDNA level increased in the blood of pregnant women and the risk for fetal intrauterine infection also increased. Threatened premature labor in fetal infection group was higher than that in control group（P